Key result
Cardiac transplant recipients on chronic immunosuppressive therapy expressed a higher combined percentage of different cytokine transcripts in peripheral blood than normal volunteers.
Population
99 biopsy samples and 89 blood samples from 65 and 35 Stanford Medical Center cardiac transplant recipients…
Design
Cohort
Authors
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Elevated peripheral cytokine transcripts may signal persistent immune activation despite immunosuppression; hypothesis-generating for rejection biomarker development.
Observational (n=100)
No
Cytokine gene expression, particularly IL-7, may serve as a biomarker for monitoring mild acute rejection in cardiac allograft recipients.
Wu et al. (1994) conducted an observational in Cardiac allograft recipients (n=100). Cardiac transplantation and chronic immunosuppressive therapy vs. Normal volunteers was evaluated on Cytokine mRNA transcripts expression. Cardiac transplant recipients on chronic immunosuppressive therapy expressed a higher combined percentage of different cytokine transcripts in peripheral blood than normal volunteers.
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