May 1, 1994Transplantation
Local Production of Cytokines in the Human Cardiac Allograft
Why the study?
Does local cytokine expression correlate with histological rejection in cardiac transplant recipients?
Population
12 cardiac transplant recipients undergoing sequential endomyocardial biopsies
Design
Cohort
Follow-up
4 months
Authors
Discussion
Loading...
Member takes
Implication
May support noninvasive rejection surveillance in transplants; observational data leave clinical utility open pending prospective validation.
Structured PICO
Does local cytokine expression correlate with histological rejection in cardiac transplant recipients?
P
Population
12 cardiac transplant recipients undergoing sequential endomyocardial biopsies
I
Intervention
Measurement of cytokine expression (IL-2, TNF beta, IL-4, IL-10, TNF alpha, IL-1 beta) via RT-PCR
O
Outcome
Correlation of cytokine expression with histopathological and clinical indicators of rejectionsurrogate
Local expression of IL-2 and IL-4 in cardiac allografts correlates with histological grades of rejection, suggesting a role in modulating rejection.
Cite This Study
Cunningham et al. (1994) studied this question.