What question did this study set out to answer?

To characterize the temporal sequence of cytokine gene expression during cardiac allograft rejection to identify molecular mechanisms for targeted therapy.

August 1, 1992Transplantation

Cytokine Gene Expression in Rejecting Cardiac Allografts

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Authors

CWCatherine J. WuBroad Institute MLMichael LovettImperial College London JWJOLENE WONG-LEE

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Implication

Preclinical study reveals early cytokine expression prior to histologic cardiac allograft rejection in cynomolgus monkeys, indicating targets for earlier diagnosis and targeted immunosuppression.

Key Points

To characterize the temporal sequence of cytokine gene expression during cardiac allograft rejection to identify molecular mechanisms for targeted therapy.
Performed heterotopic abdominal cardiac allografts in cynomolgus monkeys.
Obtained serial tissue biopsies from donor hearts pretransplant and at multiple timepoints post-surgery.
Assayed cytokine messenger RNA transcripts using the polymerase chain reaction (PCR).
Pretransplant donor heart samples lacked detectable cytokine transcripts, with the exception of IL-6 and IL-8.
IFN-gamma transcripts were detectable in all allografts two days after surgery, preceding histological signs of tissue rejection.
Minimal rejection coincided with the emergence of IL-1 beta, IL-2, and IL-6 transcripts, expanding to IL-1 alpha, IL-1 beta, IL-2, IL-6, IL-8, TNF-beta, and IFN-gamma at advanced stages.

Cite This Study

Wu et al. (1992) studied this question.

synapsesocial.com/papers/6a6f75dde71d69abee08072a https://doi.org/10.1097/00007890-199208000-00024

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Implication

Preclinical study reveals early cytokine expression prior to histologic cardiac allograft rejection in cynomolgus monkeys, indicating targets for earlier diagnosis and targeted immunosuppression.

Cytokine Gene Expression in Rejecting Cardiac Allografts

Discussion

Member takes

Implication

Key Points

Cite This Study

Cytokine Gene Expression in Rejecting Cardiac Allografts

Discussion

Member takes

Implication

Key Points

Cite This Study

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