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August 1, 1991The Journal of Experimental MedicineOpen Access

Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.

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Population

Mouse heterotopic cardiac transplant model

Comparison

Allogeneic heart grafting vs Syngeneic heart grafting and normal heart tissue

Design

Preclinical

Authors

MDMargaret J. DallmanImperial College LondonCLChristian P. LarsenEmory HealthcarePMPeter J. MorrisMenzies School of Health Research

Discussion

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Implication

No immediate clinical implications for transplantation; hypothesis-generating for cytokine-targeted rejection mechanisms in humans.

Structured PICO

P
Population
Mouse heterotopic cardiac transplant model
I
Intervention
Allogeneic heart grafting
C
Comparator
Syngeneic heart grafting and normal heart tissue
O
Outcome
Cytokine gene transcription levels assessed by semiquantitative PCRsurrogate

Allogeneic cardiac grafts exhibit a distinct cytokine transcription profile characterized by exclusive expression of IL-2, IL-4, and TNF beta compared to syngeneic grafts.

Cite This Study

Dallman et al. (1991) studied this question.

synapsesocial.com/papers/6a6f75dde71d69abee08072ehttps://doi.org/10.1084/jem.174.2.493

Topics

Heart transplantation
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat.1985 · 158 citations
  2. 2Interleukin (IL) 4 counteracts the helper effect of IL 2 on antigen‐activated human B cells1989 · 28 citations
  3. 3Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.1986 · 1,559 citations