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October 1, 1996Transplantation

Expression of Cytokine Messenger Rna After Heart Transplantation

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Population

24 human cardiac transplant recipients (187 biopsy specimens)

Design

Cohort

Follow-up

5-555 days after transplantation

Authors

SGSimon C.D. GrantSwedish Chemicals AgencySGSimon P. GuySt. Mary’s HospitalWLWilliam R. LambSt Mary's Hospital

Discussion

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Implication

IL-10 mRNA was associated with milder rejection after heart transplant; leaves open whether cytokine profiling can guide immunosuppression.

Structured PICO

P
Population
24 human cardiac transplant recipients (187 biopsy specimens)
I
Intervention
Measurement of cytokine mRNA (interleukin-2, -4, -6, -10, tumor necrosis factor-alpha, and interferon-gamma) expression in biopsy specimens and serum cytokine levels
O
Outcome
Correlation of cytokine mRNA expression with cardiac allograft rejection grade (grades 0 and 1 vs. grades 2 and 3)surrogate

Expression of T helper 2 cytokines (IL-10, IL-4) may suppress graft rejection, whereas T helper 1 cytokines (IL-2) may promote cellular rejection after heart transplantation.

Cite This Study

Grant et al. (1996) studied this question.

synapsesocial.com/papers/6a98f4ad2beb1e1a0778c8abhttps://doi.org/10.1097/00007890-199610150-00007

Topics

Heart transplantation
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CYTOKINE GENE EXPRESSION IN REJECTING CARDIAC ALLOGRAFTS1992 · 106 citations
  2. 2Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction.1991 · 264 citations
  3. 3SERUM CYTOKINES IN HUMAN HEART TRANSPLANT RECIPIENTS1996 · 38 citations
  4. 4Cytokine gene expression in human cardiac allograft recipients1994 · 27 citations
  5. 5ALLOANTIGEN-DEPENDENT ENDOTHELIAL PHENOTYPE AND LYMPHOKINE mRNA EXPRESSION IN REJECTING MURINE CARDIAC ALLOGRAFTS1993 · 49 citations