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August 1, 1996Transplantation

Serum Cytokines in Human Heart Transplant Recipients

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Key result

Serum cytokine levels showed no systematic or significant relationship with histological rejection or infection in cardiac transplant recipients.

Why the study?

Do serum cytokine levels correlate with histological rejection or infection in heart transplant recipients?

Population

28 consecutive heart transplant recipients

Design

Cohort

Follow-up

median 357 days (range 2 to 566 days)

Authors

SGSimon C.D. GrantSwedish Chemicals AgencyWLWilliam R. LambSt Mary's HospitalNBNicholas BrooksQueen Mary University of London

Discussion

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Overview

Serum cytokines lack utility as biomarkers for rejection or infection; leaves open the search for reliable noninvasive monitoring in heart transplant recipients.

Study Design

Type

Cohort (n=28)

Structured PICO

Do serum cytokine levels correlate with histological rejection or infection in heart transplant recipients?

P
Population
28 consecutive heart transplant recipients followed for a median of 357 days to investigate the relationship between serum cytokines and rejection.
O
Outcome
Relationship between serum cytokine levels (IL-2, 4, 6, 10, TNF-alpha, IFN-gamma) and histological rejection or infectionsurrogate

Serum cytokine levels do not systematically correlate with histological rejection or infection in heart transplant recipients, limiting their utility as biomarkers for these complications.

Cite This Study

Grant et al. (1996) conducted a cohort in Cardiac transplant recipients (n=28). Serum cytokine levels was evaluated on Histological rejection or infection. Serum cytokine levels showed no systematic or significant relationship with histological rejection or infection in cardiac transplant recipients.

synapsesocial.com/papers/6a97d427883af1d6c8a68233https://doi.org/10.1097/00007890-199608270-00010
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Raised serum levels of cachectin/tumor necrosis factor alpha in renal allograft rejection.1987 · 205 citations
  2. 2Cytokine mRNA expression in endomyocardial biopsies during acute rejection from human heart transplants1994 · 69 citations
  3. 3Expression of cytokine genes in human cardiac allografts: correlation of IL-6 and transforming growth factor-beta (TGF-β) with histological rejection1993 · 49 citations