Key result
Serum levels of sIL-2R increased significantly early after heart transplant compared to pre-transplant levels (1197 vs 596; p < 0.01) but did not correlate with acute rejection episodes.
Why the study?
Do serum levels of soluble interleukin-2 receptor (sIL-2R) correlate with the occurrence and degree of acute rejection in heart transplant patients?
Population
52 patients submitted to orthotopic cardiac transplant
Design
Cohort
Follow-up
regular intervals after the transplant (following weeks)
Authors
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sIL-2R monitoring does not aid acute rejection detection post-heart transplant; leaves open its role as immunosuppression intensity marker.
Observational (n=52)
Do serum levels of soluble interleukin-2 receptor (sIL-2R) correlate with the occurrence and degree of acute rejection in heart transplant patients?
Absolute Event Rate: 1197% vs 596%
p-value: p=< 0.01
Serum sIL-2R levels do not correlate with acute rejection in heart transplant patients, but may reflect the type of prophylactic immunosuppression used.
Ippoliti et al. (1990) conducted an observational in heart transplant (n=52). Serum levels of soluble interleukin-2 receptor (sIL-2R) vs. Pre-transplant levels was evaluated on sIL-2R levels early after transplant vs pre-transplant (p=< 0.01). Serum levels of sIL-2R increased significantly early after heart transplant compared to pre-transplant levels (1197 vs 596; p < 0.01) but did not correlate with acute rejection episodes.
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