Key result
The presence of CD4(T4)-IL-2R cells correlated with rejection or infection within the first 5 weeks posttransplantation with 79% sensitivity and 97% specificity (P<0.001).
Why the study?
Does measurement of CD4(T4)-IL-2R cells predict rejection or infection in cardiac transplant recipients?
Population
24 consecutive cardiac transplant recipients receiving cyclosporine and prednisone, who survived greater…
Design
Cohort
Follow-up
> 5 weeks
Authors
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May support noninvasive monitoring for rejection in cardiac transplant patients; leaves open confirmation in larger prospective studies.
Observational (n=24)
Does measurement of CD4(T4)-IL-2R cells predict rejection or infection in cardiac transplant recipients?
p-value: p=<0.001
Measurement of CD4(T4)-IL-2R cells in peripheral blood is highly correlated with early rejection in cardiac transplant patients and may be a useful tool for immunologic monitoring.
Roodman et al. (1988) conducted an observational in Cardiac transplantation (n=24). Presence of CD4(T4)-IL-2R cells was evaluated on Rejections or infection occurring within the first 5 weeks posttransplantation (p=<0.001). The presence of CD4(T4)-IL-2R cells correlated with rejection or infection within the first 5 weeks posttransplantation with 79% sensitivity and 97% specificity (P<0.001).
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