What question did this study set out to answer?

To evaluate the correlation between cardiac rejection grade scores and the expression levels of major histocompatibility complex (MHC) class I and class II antigens on myocytes and endothelial cells.

May 1, 1988Transplantation

Major Histocompatibility Complex Class I and Class Ii Expression by Myocytes in Cardiac Biopsies Posttransplantation

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Why the study?

Does MHC class I and class II expression on cardiac biopsies predict or correlate with cardiac rejection episodes posttransplantation?

Population

85 cardiac biopsies from patients 23-265 days posttransplant

Design

Cohort

Follow-up

23-265 days posttransplant

Authors

AAA. Ahmed‐AnsariEmory University TTTalaat S. TadrosGrady Memorial Hospital WKWilliam D. KnopfSaint Joseph's Hospital

Discussion

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Implication

May precede severe rejection without correlating to grades; hypothesis-generating for biopsy surveillance and requires prospective validation.

Key Points

To evaluate the correlation between cardiac rejection grade scores and the expression levels of major histocompatibility complex (MHC) class I and class II antigens on myocytes and endothelial cells.
Analyzed 85 posttransplant cardiac biopsies obtained from patients between 23 and 265 days following transplantation.
Assessed MHC class I and II expression on cardiac myocytes and endothelial cells alongside leukocyte infiltration levels and immunophenotyping.
No absolute correlation was found between histological rejection grade scores and the levels of MHC class I or class II antigen expression.
Leukocytic infiltrate quantitation did not show an absolute correlation with relative MHC antigen expression levels.
Elevated MHC class I and class II expression was detected up to four weeks prior to histological grade 4 rejection episodes in initial and serial patient biopsies.

Structured PICO

Does MHC class I and class II expression on cardiac biopsies predict or correlate with cardiac rejection episodes posttransplantation?

Population

85 cardiac biopsies from patients 23-265 days posttransplant

Intervention

Measurement of major histocompatibility complex (MHC) class I and class II expression on cardiac myocytes and endothelial cells

Outcome

Correlation of rejection grade score with the level of MHC class I and class II expression, quantitative level of leukocytic infiltrate, and immunophenotype of leukocytessurrogate

MHC class I and II expression on cardiac biopsies may serve as an early marker for monitoring cardiac rejection episodes posttransplantation.

Cite This Study

Ahmed‐Ansari et al. (1988) studied this question.

synapsesocial.com/papers/6a721e7c6ceb2bbd16e04d12 https://doi.org/10.1097/00007890-198805000-00027

Topics

Heart transplantation

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Implication

May precede severe rejection without correlating to grades; hypothesis-generating for biopsy surveillance and requires prospective validation.

Major Histocompatibility Complex Class I and Class Ii Expression by Myocytes in Cardiac Biopsies Posttransplantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Major Histocompatibility Complex Class I and Class Ii Expression by Myocytes in Cardiac Biopsies Posttransplantation

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider