What question did this study set out to answer?

To evaluate the expression of monomorphic determinants of class I and class II major histocompatibility antigens in human heart tissue before and after orthotopic cardiac transplantation.

June 1, 1986Transplantation

Expression of Class I and Class Ii Major Histocompatability Antigens in Normal and Transplanted Human Heart

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Why the study?

Does orthotopic cardiac transplantation alter the expression of class I and class II histocompatibility antigens in human hearts?

Population

35 human heart biopsy specimens

Comparison

Orthotopic cardiac transplantation vs Nontransplanted normal hearts

Design

Cross-sectional

Follow-up

5-270 days post-transplantation

Authors

MRMarlene L. RoseHarefield Hospital MCM. I. ColesHarefield Hospital RGRobert J. GriffinNational Institutes of Health

Discussion

Member takes

Implication

Upregulated MHC antigens in allografts may heighten immune targeting; leaves open causal links to rejection and need for prospective validation.

Key Points

To evaluate the expression of monomorphic determinants of class I and class II major histocompatibility antigens in human heart tissue before and after orthotopic cardiac transplantation.
Examined 35 cardiac biopsy specimens using monoclonal antibodies and an immunoperoxidase technique.
Evaluated 7 control specimens from non-transplanted hearts and 28 specimens from patients who underwent orthotopic cardiac transplantation 5 to 270 days prior.
Class I antigen was absent from the myocardial surface in normal hearts but was strongly expressed on the outer myocardial surface and intercalated discs in 24 of 28 post-transplant specimens.
Class II antigen was absent from the myocardium in both normal and transplanted hearts, but interstitial expression increased in 20 of 25 transplant specimens evaluated.

Structured PICO

Does orthotopic cardiac transplantation alter the expression of class I and class II histocompatibility antigens in human hearts?

Population

35 human heart biopsy specimens (7 from nontransplanted normal hearts and 28 from patients who received orthotopic cardiac transplantation 5-270 days previously)

Intervention

Orthotopic cardiac transplantation

Comparator

Nontransplanted normal hearts

Outcome

Expression of monomorphic determinants of class I and class II histocompatibility antigenssurrogate

Cardiac transplantation induces increased expression of class I and class II histocompatibility antigens on the myocardium and interstitial structures, potentially making the graft a target for cytotoxic T cells.

Cite This Study

Rose et al. (1986) studied this question.

synapsesocial.com/papers/6a8a94deab4588dbccfba9a0 https://doi.org/10.1097/00007890-198606000-00021

Topics

Heart transplantation

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Implication

Upregulated MHC antigens in allografts may heighten immune targeting; leaves open causal links to rejection and need for prospective validation.

Expression of Class I and Class Ii Major Histocompatability Antigens in Normal and Transplanted Human Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Expression of Class I and Class Ii Major Histocompatability Antigens in Normal and Transplanted Human Heart

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider