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June 6, 2026The Journal of Sexual Medicine

(245) Efficacy and Tolerability of a Novel Formulation Using a Sildenafil Oral Suspension in Patients with Moderate-To-Severe Erectile Dysfunction

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Authors

MCM CoschignanoUniversity of InsubriaNSN SchifanoOspedale di Circolo e Fondazione MacchiPCP CapogrossoOspedale di Circolo e Fondazione Macchi

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Implication

Randomized trial evaluates sildenafil oral suspension efficacy in erectile dysfunction, suggesting improved compliance and tolerability.

Key Points

  • The aim is to assess the efficacy, safety, and patient adherence to a novel sildenafil oral suspension formulation in treating moderate-to-severe erectile dysfunction.
  • Data from 27 PDE5I-naive patients were collected prospectively.
  • Patients ingested eight puffs (approximately 100mg) of sildenafil suspension before intercourse and were encouraged to adjust the dosage based on their response and side effects.
  • The International Index of Erectile Function (IIEF-5) questionnaire was used at baseline and after 12 months.
  • The median IIEF-5 score increased by 7 points at 12 months in compliant patients (p < 0.01).
  • Nine out of 16 patients reduced their dosage by up to 50% due to satisfactory effects and minor side effects like headaches.
  • Eight out of 24 patients discontinued or switched treatment by the 12-month follow-up.

Cite This Study

Coschignano et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76d43https://doi.org/10.1093/jsxmed/qdag118.223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1(115) Real-World Evaluation of Onset of Action and Efficacy of a Novel Sildenafil Oral Suspension in Men with Erectile Dysfunction2026
  2. 2(187) Efficiency and Safety of Combining Long-Acting and Short-Acting PDE5 Inhibitors2024
  3. 3THE ANALYSIS STUDY OF EFFECTIVENESS AND SAFETY OF ORAL SILDENAFIL CITRATE FOR TREATMENT OF ERECTILE DYSFUNCTION : A COMPREHENSIVE SYSTEMATIC REVIEW2024
  4. 4Pharmacokinetic Parameters of a Novel Sildenafil Oral Liquid Suspension Administered to Healthy Adult Men Under Fasted Conditions2024 · 1 citations
  5. 5Oral drug treatments of erectile dysfunction: A AFU/SFMS systematic review2025 · 1 citations