Protective Effect of Garlic on Diazinon Induced Kidney Toxicity in Rat: A Biochemical and Histopathological Evaluation.

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Garlic extract mitigates diazinon-induced nephrotoxicity and oxidative stress in rats by reversing oxidative stress status and ameliorating histopathological injuries. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Saeed Afzali; Behnaz Alafchi; Elham Shiri; Fereshteh Mehri

doi:10.61882/ijkd.20.01.8158

February 25, 2026

Protective Effect of Garlic on Diazinon Induced Kidney Toxicity in Rat: A Biochemical and Histopathological Evaluation.

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Key Points

This research aims to evaluate the protective effects of garlic on kidney toxicity induced by diazinon in rats.
Male Wistar rats were treated with diazinon (70 mg/kg/day) and/or garlic extract (500 mg/kg) orally for four weeks.
Biochemical markers of oxidative stress and kidney histopathology were assessed after treatment.
Biomarkers measured included malondialdehyde, total antioxidant capacity, catalase, superoxide dismutase, and total thiol molecules.
DZN treatment significantly increased MDA levels (p<0.05) and decreased levels of CAT, SOD, TAC, and total thiol molecules.
Co-treatment with garlic extract reversed the oxidative stress changes induced by DZN.
Garlic improved the kidney histopathology affected by DZN.

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Implication

Evaluates garlic's protective effect on kidney toxicity in rats, suggesting its use as a mitigative agent.

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Afzali et al. (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76deb https://doi.org/10.61882/ijkd.20.01.8158

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Protective Effect of Garlic on Diazinon Induced Kidney Toxicity in Rat: A Biochemical and Histopathological Evaluation.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Protective Effect of Garlic on Diazinon Induced Kidney Toxicity in Rat: A Biochemical and Histopathological Evaluation.

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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