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June 6, 2026The Journal of Headache and PainOpen Access

Migraine and menopause as converging factors in brain vulnerability: a hypothesis-driven perspective

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Authors

PGParisa Gazerani

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Overview

Hypothesis-driven narrative explores migraine's impact on brain health in menopausal women, suggesting altered neural vulnerability.

Key Points

  • This work aims to explore the relationship between migraine and menopause in the context of brain health and vulnerability.
  • Synthesized evidence from clinical studies, neuroimaging, and mechanistic research.
  • Proposed a conceptual neuroendocrine framework linking migraine processes with hormonal changes during menopause.
  • Highlighted the need for longitudinal studies to investigate migraine's role in cognitive outcomes.
  • Neuroimaging studies show overlapping alterations between migraine and biological processes in brain aging.
  • Evidence suggests that the menopausal transition may reveal previously compensated neural differences.
  • Migraine may serve as an indicator of altered neural vulnerability rather than a direct cause of neurodegeneration.

Cite This Study

Parisa Gazerani (2026) studied this question.

synapsesocial.com/papers/6a23bb4471a5da9775e76e13https://doi.org/10.1186/s10194-026-02404-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Migraine and the menopause transition2026
  2. 2Migraine across the menopausal transition and beyond: A narrative review2026 · 3 citations
  3. 3The Neurology of Menopause2026
  4. 4Accelerated brain aging in migraine: a multilevel MRI-based brain age modeling study2026
  5. 5Sex Differences in Migraine: Bridging Pathophysiology and Clinical Care in Women2025 · 4 citations