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June 6, 2026npj gut and liver.Open Access

Diversity in metabolic dysfunction-associated steatotic liver disease: a framework for precision medicine

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Authors

DKDonghyun KoBridgeport HospitalJLJordan LowNational University of SingaporePLPéter LőwNational University of Singapore

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Overview

Narrative review synthesizes evidence on metabolic dysfunction-associated steatotic liver disease diversity, suggesting precision medicine strategies.

Key Points

  • The aim is to explore the biological and clinical variability in metabolic dysfunction-associated steatotic liver disease (MASLD) and how this impacts disease management.
  • Narrative review synthesizing evidence on MASLD heterogeneity.
  • Analysis of genetic, histologic, clinical, and microbiome factors influencing MASLD.
  • Integration of data concerning disease mechanisms and therapeutic responses.
  • Identified broad spectrum of factors influencing MASLD, including genetic and environmental.
  • Highlighted distinct disease trajectories based on histopathology and phenotypes.
  • Emphasized potential for tailored precision medicine strategies in treating MASLD.

Cite This Study

Ko et al. (2026) studied this question.

synapsesocial.com/papers/6a23bbeb71a5da9775e774e9https://doi.org/10.1038/s44355-026-00061-3
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