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June 6, 2026Open Access

In Silico and Pharmacological Evaluation of Antidiabetic and Antioxidant Potential of Secondary Metabolites From Aegle Marmelos

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Randomized trial evaluates antidiabetic and antioxidant effects of Aegle marmelos in diabetes, indicating herbal therapy potential.

This research aims to evaluate the antidiabetic and antioxidant potential of secondary metabolites from Aegle marmelos.
In silico molecular docking studies on quercetin, rutin, and aegeline against DPP-4, α-glucosidase, and α-amylase.
Extraction of phytoconstituents from Aegle marmelos using Soxhlet extraction for evaluation.
Antidiabetic activity assessed via α-amylase inhibitory assay and antioxidant activity through FRAP assay.
Rutin exhibited the highest binding affinity against α-glucosidase and DPP-4, showing strong inhibitory activity.
Extract demonstrated concentration-dependent antidiabetic activity compared to standard drugs.
Moderate antioxidant activity was recorded during the evaluation.

*Paras Pradeep Ghule, Nikita Nitin Gaikwad, Divya Vijay Ghadge, Ravindra Y. Patil, Devyani Kirve (2026) studied this question.

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