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June 6, 2026The Journal of Sexual Medicine

(260) Combination Tadalafil and Tamsulosin Therapy Versus Monotherapy for Lower Urinary Tract Symptoms and Erectile Dysfunction: A Randomized Trial

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Authors

NMN MohammedAssiut University HospitalsAMA MostafaAssiut University HospitalsMOM E OsmanAssiut University Hospitals

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Implication

Randomized trial compares combination therapy efficacy on LUTS and erectile dysfunction in men, suggesting improved outcomes.

Key Points

  • This study aims to compare the efficacy and safety of combination therapy versus monotherapy for LUTS and ED in men with BPH.
  • Prospective, randomized clinical trial with 140 men aged >45 years.
  • Participants were assigned to one of three groups for 12 weeks: Tamsulosin alone, Tadalafil alone, or combination therapy.
  • Efficacy assessed via IPSS, Qmax, PVRU, and IIEF-5 scores.
  • Combination therapy group showed a greater median percentage improvement in IPSS (-12.4%) than Tamsulosin (-8.7%) and Tadalafil (-2.6%), p<0.001.
  • Combination therapy achieved the highest median increase in Qmax (41.0%) compared to Tamsulosin (31.9%) and Tadalafil (4.5%), p<0.001.
  • Erectile function improvement was significant with combination therapy (35.8%) compared to Tamsulosin (0.1%) and comparable to Tadalafil (34.1%), p<0.001.

Cite This Study

Mohammed et al. (2026) studied this question.

synapsesocial.com/papers/6a23bc0571a5da9775e77772https://doi.org/10.1093/jsxmed/qdag118.237
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative study of tamsulosin, tadalafil, and combination of tamsulosin with tadalafil in the treatment of patients with lower urinary tract symptoms2024 · 2 citations
  2. 2Efficacy of Tamsulosin Alone or in Combination with Tadalafil in Relieving Benign Prostatic Hyperplasia Symptoms2025
  3. 3Tadalafil and tamsulosin in the management of lower urinary tract symptoms due to benign prostatic hyperplasia: A prospective, randomized, open-label, comparative study2026
  4. 4The efficacy of vardenafil and tamsulosin in treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: A randomised clinical trial2024
  5. 5Efficacy and Safety of Mirabegron and Tamsulosin Combination Therapy Compared to Tamsulosin Monotherapy for Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: Results of a Multicenter, Randomized, Double-Blind, Phase III Clinical Trial2025 · 1 citations