What question did this study set out to answer?

This study aims to assess the diagnostic value of global longitudinal strain (GLS) from transthoracic echocardiography (TTE) in evaluating myocardial fibrosis in hypertrophic cardiomyopathy.

June 6, 2026BiomedicinesOpen Access

Echocardiographic Global Longitudinal Strain and Myocardial Fibrosis in Patients with Left Ventricular Hypertrophy and Hypertrophic Cardiomyopathy

Q: What are the key findings of this study?

Global longitudinal strain derived from echocardiography was significantly associated with myocardial fibrotic burden on CMR, showing good diagnostic performance for extensive fibrosis (AUC 0.867).

Q: What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Left ventricular hypertrophy and hypertrophic cardiomyopathy (n=83). Intervention: Global longitudinal strain (GLS) via transthoracic echocardiography vs. Cardiovascular magnetic resonance with late gadolinium enhancement. Primary outcome: Diagnostic performance for detecting LGE in more than four LV segments (AUC 0.867, p=<0.001).

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Key result

Echo-derived GLS identifies extensive myocardial fibrosis on CMR with ~0.87 AUC.

AUC 0.867
P<0.001
n=83

Why the study?

CMR with LGE is the reference standard for myocardial fibrosis in HCM but has limited availability, whereas echocardiographic GLS may provide complementary assessment of myocardial involvement.

Does transthoracic echocardiography with global longitudinal strain correlate with myocardial fibrosis assessed by CMR in patients with left ventricular hypertrophy?

Population

83 patients with suspected HCM or LV hypertrophy referred for CMR

Comparison

TTE with 2D GLS vs CMR with LGE

Design

Cross-sectional diagnostic study

Authors

MMM Matla-HajzykMedical University of Silesia MBMariusz BałysMedical University of Silesia AOAleksander OlejnikMedical University of Silesia

Discussion

Member takes

Implication

May support adjunctive GLS for fibrosis assessment in LVH; leaves open prospective validation before clinical adoption.

Key Points

This study aims to assess the diagnostic value of global longitudinal strain (GLS) from transthoracic echocardiography (TTE) in evaluating myocardial fibrosis in hypertrophic cardiomyopathy.
95 patients were screened for eligibility; 83 patients were included after exclusions.
All participants underwent cardiovascular magnetic resonance (CMR) and transthoracic echocardiography (TTE) with GLS assessment.
The relationship between GLS and the extent of myocardial fibrosis was analyzed using regression techniques.
GLS was significantly lower in patients with late gadolinium enhancement (LGE) compared to those without (−13.9 ± 3.6% vs. −15.9 ± 2.7%, p = 0.01).
GLS showed a moderate positive correlation with the extent of myocardial fibrosis (r = 0.45, p < 0.01).
An AUC of 0.867 was observed for detecting LGE in patients with >4 LV segments, with a sensitivity of 72% and specificity of 87% (p < 0.001).

Study Design

Type

Cross-Sectional (n=83)

Structured PICO

Does transthoracic echocardiography with global longitudinal strain correlate with myocardial fibrosis assessed by CMR in patients with left ventricular hypertrophy?

Population

83 patients with suspected hypertrophic cardiomyopathy or left ventricular hypertrophy who underwent both CMR and TTE with GLS assessment.

Exposure

Transthoracic echocardiography (TTE) with 2D global longitudinal strain (GLS)

Comparator

Cardiovascular magnetic resonance (CMR) with late gadolinium enhancement (LGE) as the reference standard

Outcome

Diagnostic value and correlation of GLS to detect the degree of myocardial fibrosis (LGE)surrogate

Main Result

Effect estimate: AUC 0.867

p-value: p=<0.001

Echocardiographic global longitudinal strain correlates with myocardial fibrosis on CMR and may serve as an adjunctive tool to identify fibrotic burden in patients with left ventricular hypertrophy.

Cite This Study

Matla-Hajzyk et al. (2026) conducted a cross-sectional in Left ventricular hypertrophy and hypertrophic cardiomyopathy (n=83). Global longitudinal strain (GLS) via transthoracic echocardiography vs. Cardiovascular magnetic resonance with late gadolinium enhancement was evaluated on Diagnostic performance for detecting LGE in more than four LV segments (AUC 0.867, p=<0.001). Global longitudinal strain derived from echocardiography was significantly associated with myocardial fibrotic burden on CMR, showing good diagnostic performance for extensive fibrosis (AUC 0.867).

synapsesocial.com/papers/6a23bc2a71a5da9775e77900 https://doi.org/10.3390/biomedicines14061278

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Echocardiographic Global Longitudinal Strain and Myocardial Fibrosis in Patients with Left Ventricular Hypertrophy and Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Echocardiographic Global Longitudinal Strain and Myocardial Fibrosis in Patients with Left Ventricular Hypertrophy and Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

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