Beneficial Effects of Quadri Herb (QH) Ointment on Second‐Degree Burn Scald: An In Vivo Study

BACKGROUND: Burn injuries are known as one of the main reasons for hospitalizations across the globe. Scalds, which are considered as wet burns, are more common. Many procedures are used to manage the wound healing process; using silver sulphadiazine 1% is one of those routine ways. However, nowadays, traditional medicine findings, along with modern medications, can cooperate with each other to lead to perfect wound care. Thus, the usage of medicinal plants is suggested for this purpose; so, the aim of the present study is to investigate the beneficial effects of a quadri herb (QH) ointment based on of medicinal plants: Scrophularia striata, Artemisia aucheri, Falcaria vulgaris, and Aloe vera on second-degree burn scald. METHODS: A total of 42 male Wistar rats were grouped into 7; after induction of burn scald by the use of hot water, treated groups received QH ointment in concentrations of 0.5%, 1%, 2%, and 5% with respect to herbal extracts; the wound healing process was monitored for 16 days and the results were statistically analyzed. On the final day of intervention, rats were sacrificed, and skin biopsies were used for histopathological evaluations. RESULTS: Significant reduction of wound percentage (p ≤ 0.05) among 2% and 5% groups showed that QH ointment performed better in wound healing compared with the control and positive control groups. Histological analysis also revealed significant increases in granulation and vascular-fibroblast density with 5% of QH ointment (p ≤ 0.01). CONCLUSION: It concludes that QH ointment has remarkable effects in the healing of second-degree burn scalds.