Key result
AKI-to-AKD transition with worsening pulmonary hypertension linked to long-term eGFR decline, unlike early AKI reversal.
Why the study?
Pulmonary hypertension is frequently accompanied by a decline in kidney function.
Does the transition from AKI to AKD compared to early AKI reversal predict long-term eGFR decline in patients with worsening pulmonary hypertension?
Cohort
Does the transition from AKI to AKD compared to early AKI reversal predict long-term eGFR decline in patients with worsening pulmonary hypertension?
Answers are grounded in this paper and cite their sources.
In patients with pulmonary hypertension, long-term kidney function decline is driven by persistent acute kidney disease rather than transient acute kidney injury.
Pulmonary hypertension (PH) is frequently accompanied by a decline in kidney function. In this retrospective cohort, worsening PH was associated with long‐term eGFR decline only when accompanied by transition from acute kidney injury (AKI) to acute kidney disease (AKD), defined as persistent kidney dysfunction beyond 7 days after AKI onset, whereas early AKI reversal was not. These findings suggest that renal recovery patterns, rather than transient changes in kidney function, may determine longitudinal kidney outcomes in PH and warrant further prospective investigation.
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Hintz et al. (2026) conducted a cohort in Pulmonary hypertension. Worsening pulmonary hypertension accompanied by transition from acute kidney injury to acute kidney disease vs. Early AKI reversal was evaluated on Long-term eGFR decline. Worsening pulmonary hypertension accompanied by transition from acute kidney injury to acute kidney disease was associated with long-term eGFR decline, whereas early AKI reversal was not.
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