Key result
The apolipoprotein E4 allele frequency was significantly higher in patients with type V hyperlipoproteinemia compared to normal volunteers (51.7% vs 13.5%, p<0.01).
Population
67 subjects total: 30 patients with type V hyperlipoproteinemia and 37 normal volunteers. Key inclusion for…
Design
Case-control
Authors
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E4 association with type V hyperlipoproteinemia is hypothesis-generating; leaves open any diagnostic or therapeutic role pending prospective studies.
Case-Control (n=67)
No
Absolute Event Rate: 51.7% vs 13.5%
p-value: p=<0.01
The apolipoprotein E4 allele is significantly more prevalent in patients with type V hyperlipoproteinemia, suggesting it may play a role in the pathogenesis of the disorder.
Ghiselli et al. (1982) conducted a case-control in Type V hyperlipoproteinemia (n=67). Type V hyperlipoproteinemia vs. Normal volunteers was evaluated on Apolipoprotein E4 allele frequency (p=<0.01). The apolipoprotein E4 allele frequency was significantly higher in patients with type V hyperlipoproteinemia compared to normal volunteers (51.7% vs 13.5%, p<0.01).
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