Key result
Apolipoprotein B-48 of rat chylomicrons is not a precursor of the B apoprotein of low density lipoproteins, as no 125I-labeled apo B-48 was found in B-100 or B-95 apolipoproteins.
Population
Rats with intestinal lymph fistulas
Design
Preclinical
Follow-up
1 hr
Authors
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Rat findings rule out apo B-48 as LDL precursor; leaves open species differences and human lipoprotein pathways for further study.
Unlike apo B from VLDL, apo B-48 from chylomicrons does not serve as a precursor for LDL apolipoproteins in rats.
Hooft et al. (1982) studied this question. 125I-labeled apo B-48 of intestinal lymph chylomicrons was evaluated on Presence of 125I in B-100 or B-95 apolipoproteins. Apolipoprotein B-48 of rat chylomicrons is not a precursor of the B apoprotein of low density lipoproteins, as no 125I-labeled apo B-48 was found in B-100 or B-95 apolipoproteins.
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