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Demonstrates the potential of phage therapy in enhancing effectiveness against resistant bacteria, suggesting new treatment strategies.
Abstract Phage therapy often fails when bacteria evolve resistance. We argue that phage selection should begin with receptors whose modification imposes predictable costs, turning resistance into reduced virulence, antibiotic resensitization, or other exploitable trade-offs. Receptor-constrained evolutionary traps offer a framework for designing phages that steer—not merely suppress—bacterial evolution effectively.
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Zhang et al. (2026) studied this question.
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