Key result
Cytokines regulate inflammation in CHD and offer clinical value for risk assessment, prognosis, and targeted therapy.
Why the study?
Coronary heart disease is a prevalent condition with increasing mortality where inflammation plays a key pathogenic role involving cytokines.
Cytokines play a critical role in the pathogenesis of coronary heart disease and represent promising targets for risk assessment and personalized therapy.
May inform cytokine-based CHD risk stratification; leaves open whether targeted modulation improves outcomes.
Coronary heart disease (CHD) is a prevalent cardiovascular condition with increasing prevalence and mortality, where inflammation plays a key pathogenic role. Cytokines, critical mediators of immune and inflammatory responses, are closely involved in CHD progression by regulating inflammation, myocardial apoptosis, endothelial dysfunction, and vascular smooth muscle cell proliferation. It introduces cytokines’ basic properties, elaborates on pro-inflammatory (TNF-α, IL-1, IL-6) and anti-inflammatory (IL-10, TGF-β) cytokines’ specific effects on atherosclerosis and cardiomyocyte function, and discusses their clinical value in risk assessment, prognosis, and targeted therapy. Existing research gaps and future directions (e.g., advanced technologies, personalized therapies) are highlighted. This review provides a comprehensive overview to inform CHD basic research and clinical management.
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(41392) et al. (2026) conducted a review in Coronary heart disease (CHD). Cytokines was evaluated. Cytokines play a critical role in coronary heart disease progression by regulating inflammation and offer clinical value in risk assessment, prognosis, and targeted therapy.
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