(855) Effectiveness of Gabapentin in the Treatment of Vulvodynia: Observations from a Small Clinical Sample

Introduction Vestibulodynia, a subtype of vulvodynia characterized by localized pain at the vaginal vestibule, often leads to marked physical discomfort, sexual avoidance, and emotional distress. Women experiencing this condition frequently internalize guilt and fear associated with pain and intimacy. Such psychological responses can exacerbate the overall impact of genital pain and delay treatment. Gabapentin, a neuromodulatory agent, has shown potential for reducing neuropathic pain and improving sexual function in women with chronic vulvar pain. Objective This study aimed to evaluate both the clinical and emotional outcomes of gabapentin treatment in women diagnosed with vestibulodynia, emphasizing the relationship between pain reduction, self-perception, and psychosexual recovery. Methods Forty-eight women diagnosed with vestibulodynia during consultations with medical sexologists received individualized treatment plans that included gabapentin 300 mg daily, prescribed and titrated according to clinical tolerance and response. Pain intensity was evaluated using a visual analog scale (VAS), and follow-up assessments explored changes in sexual comfort, emotional state, and self-image. Semi-structured interviews addressed perceptions of intimacy, fear, and guilt before and after treatment. Quantitative and qualitative data were analyzed together to capture both physical and psychosocial dimensions of improvement. Results Following gabapentin treatment, 23 of the 48 participants (47.9%) reported significant positive changes. Their VAS pain scores decreased from a baseline of 8–9 to 1–2, accompanied by marked reductions in burning sensations and hypersensitivity. Participants described emotional relief and greater trust in their bodies, with several expressing that “the fear is gone” and “intimacy feels possible again.” Improved physical comfort was closely linked with decreased guilt and avoidance behaviors, enhanced partner closeness, and renewed sexual confidence. No major side effects or discontinuations were recorded during the treatment period. Conclusions Gabapentin, as part of physician-directed management, demonstrated substantial benefits for nearly half of the women treated, reducing both physical pain and the psychological burden of vestibulodynia. Pain relief was often experienced as an emotional liberation-transforming self-perception from shame and fear to comfort and connection. Effective symptom control may also facilitate psychosexual healing. Integrating medical therapy with empathic, individualized psychosexual support is recommended for comprehensive care. Disclosure No