Key result
Longer duration of subsyndromal symptoms in the first 6 months after remission of late-life depression was significantly associated with a higher recurrence rate (HR 1.16; 95% CI 1.08-1.24).
Why the study?
Does the duration of subsyndromal symptoms after remission predict recurrence in older patients with late-life depression?
Population
185 older in-patients and out-patients with unipolar major depression who achieved remission after…
Comparison
Presence and duration of subsyndromal depressive… vs Absence or shorter duration of subsyndromal…
Design
Cohort
Follow-up
2.5 years
Authors
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May identify older adults needing closer post-remission monitoring; leaves open whether targeting subsyndromal symptoms reduces recurrence.
Cohort (n=185)
Does the duration of subsyndromal symptoms after remission predict recurrence in older patients with late-life depression?
Hazard Ratio: 1.16 (95% CI 1.08–1.24)
In older patients with late-life depression, the presence and duration of subsyndromal symptoms in the first 6 months after remission strongly predict the risk of recurrence.
Kiosses et al. (2012) conducted a cohort in Late-life depression (n=185). Longer duration of subsyndromal depressive symptoms vs. Shorter or no duration of subsyndromal symptoms was evaluated on Time to recurrence and recurrence rate (HR 1.16, 95% CI 1.08-1.24). Longer duration of subsyndromal symptoms in the first 6 months after remission of late-life depression was significantly associated with a higher recurrence rate (HR 1.16; 95% CI 1.08-1.24).
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