Key result
In isolated outer medullary descending vasa recta, 1.0 mM L-arginine increased nitric oxide generation by 13.6% (P<0.05), an effect further enhanced by bradykinin and tempol.
p-value: p=<0.05
In isolated outer medullary descending vasa recta, NO generation is increased by L-arginine and bradykinin, while superoxide reduces cellular NO concentrations.
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Hypothesis-generating for medullary NO regulation; leaves open in vivo effects on renal perfusion before any clinical consideration.
Rhinehart et al. (2001) studied this question. L-arginine, bradykinin, and tempol vs. Control vessels was evaluated on Nitric oxide (NO) generation measured by DAF-2 fluorescence (p=<0.05). In isolated outer medullary descending vasa recta, 1.0 mM L-arginine increased nitric oxide generation by 13.6% (P<0.05), an effect further enhanced by bradykinin and tempol.
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