Why the study?
Does prolonged exposure to elevated D-glucose concentrations modulate agonist-induced Ca2+ mobilization and EDRF formation in porcine aortic endothelial cells?
Population
Porcine aortic endothelial cells
Comparison
Prolonged exposure to elevated D-glucose… vs L-glucose, D-mannitol, or coincubation with…
Design
Preclinical
Authors
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Hypothesis-generating for endothelial changes in early diabetes; leaves open in vivo relevance and therapeutic implications.
Does prolonged exposure to elevated D-glucose concentrations modulate agonist-induced Ca2+ mobilization and EDRF formation in porcine aortic endothelial cells?
Elevated D-glucose concentrations amplify agonist-stimulated Ca2+ mobilization and EDRF formation in endothelial cells, potentially explaining pathological vasodilation in early diabetes.
Graier et al. (1993) studied this question.
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