Why the study?
Does human tumor necrosis factor receptor p75 play a functional role in cytokine secretion in T cells without ligand-dependent TNF-R55 involvement?
Does human tumor necrosis factor receptor p75 play a functional role in cytokine secretion in T cells without ligand-dependent TNF-R55 involvement?
The study provides direct evidence that TNF-R75 plays a functional role in inducing cytokine secretion in T cells independently of TNF-R55.
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Hypothesis-generating for TNF-R75 signaling in T cells; leaves open relevance to human disease.
Vandenabeele et al. (1992) studied this question.
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