Key result
Platelet-specific markers PF-4, TSP-1, and sCD40L correlated strongly with peak thrombin generation (r=0.55 for PF-4; p<0.001) and monocyte-platelet aggregate formation.
Population
316 patients with advanced atherosclerosis undergoing angioplasty and stenting
Design
Cohort
Authors
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Should not yet change practice in atherosclerosis; hypothesis-generating for platelet biomarker roles in thrombosis.
Observational (n=316)
Effect estimate: r=0.55
p-value: p=<0.001
Platelet-specific markers such as PF-4 and TSP-1 are significantly associated with monocyte-platelet aggregate formation and thrombin generation potential in patients with advanced atherosclerosis.
Ay et al. (2015) conducted an observational in Advanced atherosclerosis (n=316). Platelet biomarkers (PF-4, TSP-1, sCD40L, sP-selectin) was evaluated on Correlation with monocyte-platelet aggregate (MPA) formation and thrombin generation potential (r=0.55, p=<0.001). Platelet-specific markers PF-4, TSP-1, and sCD40L correlated strongly with peak thrombin generation (r=0.55 for PF-4; p<0.001) and monocyte-platelet aggregate formation.
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