Soluble Thrombomodulin Increases in Patients with Disseminated Intravascular Coagulation and in Those with Multiple Organ Dysfunction Syndrome after Trauma

October 1, 1995

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Key Points

This study investigates the role of soluble thrombomodulin and neutrophil elastase in trauma patients. It aims to understand their relationship to disseminated intravascular coagulation and multiple organ dysfunction syndrome.
Forty-seven trauma victims were analyzed, including 14 with DIC, 5 with MODS, and 28 controls.
Measurement of soluble thrombomodulin and neutrophil elastase on injury day, then days one, three, and five post-admission.
Statistical comparisons and correlations between soluble TM and neutrophil elastase were conducted.
Patients with DIC showed significantly higher soluble TM levels upon admission compared to controls (p < 0.05).
Nonsurvivors with DIC had higher soluble TM levels than survivors on days three and five (p < 0.05).
A strong correlation was found between peak soluble TM levels and injury severity score (r2 = 0.125, p < 0.025).

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Prospective case-control study shows soluble thrombomodulin elevation in trauma patients with DIC or MODS, suggesting injury severity.

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Gando et al. (1995) studied this question.

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