Why the study?
Does immunohistochemical staining for dystrophin identify symptomatic carriers of Duchenne's muscular dystrophy?
Population
3 symptomatic female carriers of Duchenne's muscular dystrophy, 9 normal subjects, and 31 patients with…
Comparison
Immunohistochemical staining of muscle-biopsy… vs Muscle specimens from normal subjects and…
Design
Case-control
Authors
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Mosaic dystrophin staining may support biopsy identification of symptomatic DMD carriers; leaves open validation in larger prospective cohorts.
Does immunohistochemical staining for dystrophin identify symptomatic carriers of Duchenne's muscular dystrophy?
Symptomatic carriers of Duchenne's muscular dystrophy can be identified by a distinct mosaic pattern of dystrophin expression in skeletal muscle biopsies.
Arahata et al. (1989) studied this question.
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