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October 1, 1991British Journal of PharmacologyOpen Access

Characterization of the interaction of R 56865 with cardiac Na‐ and L‐type Ca channels

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Population

Isolated cardiac muscle (single isolated ventricular cardiomyocytes and papillary muscles)

Comparison

R 56865 (0.1–10 μmol l−1) vs Control conditions or exposure to veratridine or…

Design

Preclinical

Authors

DWD. WilhelmJanssen (Belgium)HHHerbert M. HimmelBayer (Germany)URUrsula RavensElectrophysiology

Discussion

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Implication

May inform sodium channel modulation strategies in preclinical arrhythmia models; leaves open translation to clinical use.

Structured PICO

P
Population
Isolated cardiac muscle (single isolated ventricular cardiomyocytes and papillary muscles)
I
Intervention
R 56865 (0.1–10 μmol l−1)
C
Comparator
Control conditions (absence of R 56865) or exposure to veratridine or Anemonia sulcata toxin ATX II alone
O
Outcome
Influence on calcium and sodium currents, action potential, and contractile forcesurrogate

The protective effect of R 56865 against veratridine-induced electrical and mechanical oscillations is likely mediated by potential-dependent inhibition of the sodium current rather than calcium current.

Cite This Study

Wilhelm et al. (1991) studied this question.

synapsesocial.com/papers/6a23ce8b55bd20cf6fa63af2https://doi.org/10.1111/j.1476-5381.1991.tb12455.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The dependence of calcium efflux from cardiac muscle on temperature and external ion composition1968 · 1,025 citations
  2. 2Calcium‐activated non‐selective cation channel in ventricular cells isolated from adult guinea‐pig hearts.1988 · 195 citations
  3. 3Afterdepolarizations and triggered activity1992 · 199 citations
  4. 4Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction.1984 · 155 citations