Key result
Carbonic anhydrases and related proteins in zebrafish play important roles in acid-base balance, pigmentation, and motor coordination, with disruption potentially leading to lethal outcomes.
Why the study?
Studies in zebrafish have revealed unpredicted roles for carbonic anhydrases and related proteins across physiological processes beyond acid-base regulation, warranting a summary of current knowledge.
This review highlights the diverse physiological roles of carbonic anhydrases and related proteins in zebrafish, extending beyond acid-base balance to include pigmentation and motor coordination.
Answers are grounded in this paper and cite their sources.
Broadens carbonic anhydrase roles in zebrafish models; leaves open translation to human cardiovascular physiology.
During the last decades, zebrafish (Danio rerio) has become one of the most important model organisms to study different physiological and biological phenomena. Research field of carbonic anhydrases (CAs) and carbonic anhydrase related proteins (CARPs) is not an exception in this. The best-known known function of CAs is the regulation of acid-base balance. However, studies performed with zebrafish, among others, have revealed important roles for these proteins in many other physiological processes, some of which have been unpredicted in the light of the previous studies and suggestions. Examples are roles in zebrafish pigmentation as well as motor coordination. Disruption of the function of these proteins may generate even lethal outcomes. In this review, we summarize the current knowledge of CA-related studies performed in zebrafish.
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Aspatwar et al. (2022) conducted a review in Zebrafish physiology. Carbonic anhydrases and carbonic anhydrase related proteins was evaluated. Carbonic anhydrases and related proteins in zebrafish play important roles in acid-base balance, pigmentation, and motor coordination, with disruption potentially leading to lethal outcomes.
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