July 13, 2007European Journal of Heart Failure
Ejection Fraction and Blood Pressure are Important and Interactive Predictors of 4-Week Mortality in Severe Acute Heart Failure
Key result
Lower LVEF (OR 1.27 per 10% decrease; 95% CI 1.05-1.53) and lower MAP were independent predictors of 4-week mortality in severe acute heart failure, with LVEF risk amplified at MAP ≤90 mmHg.
Why the study?
Do LVEF and MAP independently predict 4-week mortality in patients with severe acute heart failure?
Population
355 patients with severe acute heart failure syndromes admitted to 60 CCU/ICUs with echocardiographic LVEF…
Design
Cohort
Follow-up
4 weeks
Authors
Discussion
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Member takes
Implication
May inform short-term risk stratification in acute HF; hypothesis-generating and should not yet change practice.
Study Design
Type
Cohort (n=355)
Multicenter
Yes
Structured PICO
Do LVEF and MAP independently predict 4-week mortality in patients with severe acute heart failure?
P
Population
355 patients with severe acute heart failure syndromes admitted to CCU/ICUs with available echocardiographic LVEF, followed for 4 weeks.
E
Exposure
Assessment of left ventricular ejection fraction (LVEF) and mean arterial pressure (MAP)
O
Outcome
4-week mortalityhard clinical
Main Result
Odds Ratio: 1.27 (95% CI 1.05–1.53)
p-value: p=0.012
LVEF and MAP are interactive predictors of 4-week mortality in severe acute heart failure, with LVEF offering significant prognostic value primarily when MAP is ≤90 mmHg.
Cite This Study
Adamopoulos et al. (2007) conducted a cohort in Severe Acute Heart Failure (n=355). Lower LVEF vs. Higher LVEF (per 10% decrease) was evaluated on 4-week mortality (OR 1.27, 95% CI 1.05-1.53, p=0.012). Lower LVEF (OR 1.27 per 10% decrease; 95% CI 1.05-1.53) and lower MAP were independent predictors of 4-week mortality in severe acute heart failure, with LVEF risk amplified at MAP ≤90 mmHg.