May 1, 1991Circulation
Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery. A placebo-controlled, randomized study.
Why the study?
Does aspirin 324 mg daily initiated within 1 hour of CABG improve early and late angiographic graft patency in patients undergoing CABG?
Population
Patients undergoing coronary artery bypass grafting.
Comparison
Aspirin 324 mg daily, initiated within 1 hour of… vs Placebo.
Design
RCT, Randomized, Double-blind, placebo-controlled
Follow-up
1 year
Authors
Discussion
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Member takes
Implication
Supports immediate aspirin initiation after CABG; confirms benefit in a double-blind RCT.
Structured PICO
Does aspirin 324 mg daily initiated within 1 hour of CABG improve early and late angiographic graft patency in patients undergoing CABG?
P
Population
Patients undergoing coronary artery bypass grafting (CABG) (n=231 evaluated at 1 week, n=219 evaluated at 1 year).
I
Intervention
Aspirin 324 mg daily, initiated within 1 hour of CABG and continued up to 1 year.
C
Comparator
Placebo.
O
Outcome
Angiographic graft patency at 1 week and 1 year after CABG.surrogate
Immediate postoperative administration of aspirin 324 mg daily significantly improves early and late vein graft patency after CABG without significantly increasing blood loss.
Cite This Study
Gavaghan et al. (1991) studied this question.