Deducing the conformational space for an octa-proline helix

Q: What does this research mean for the field?

An octa-proline helix dyad exists as a limited set of conformers with a narrow range of excitation energy transfer (EET) rates, whose dynamics can be accurately simulated using a distributive model based on amide group isomerization. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Sara M. A. Waly; Andrew C. Benniston; Anthony Harriman

doi:10.1039/d3sc05287g

December 21, 2023Chemical ScienceOpen Access

Deducing the conformational space for an octa-proline helix

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Key Points

The study aims to identify the conformational variations of an octa-proline helix and their impact on energy transfer rates.
Utilized time-resolved fluorescence spectroscopy to investigate conformational dynamics.
Employed DFT calculations for structural optimization and analysis of isomerization of amide groups.
Simulated EET dynamics based on optimized conformer structures.
Identified multiple conformers of the octa-proline helix with varying energy transfer rates.
Demonstrated a narrow distribution of EET rates among the observed conformers.
Established a connection between isomerization of amide groups and EET dynamics.

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Implication

Deducing conformational space in octa-proline helix reveals diverse conformers and EET dynamics.

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Cite This Study

Waly et al. (2023) studied this question.

synapsesocial.com/papers/6a23e6550f6fe640299f154a https://doi.org/10.1039/d3sc05287g

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Deducing the conformational space for an octa-proline helix

Key Points

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Implication

Abstract

Discussion

Cite This Study

Deducing the conformational space for an octa-proline helix

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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