July 1, 1979Circulation ResearchOpen Access

Central neural mechanisms of the cerebral ischemic response. Characterization, effect of brainstem and cranial nerve transections, and simulation by electrical stimulation of restricted regions of medulla oblongata in rabbit.

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Population

Anesthetized rabbits

Comparison

Cerebral ischemia induced by clamping both… vs Baseline or intact state

Design

Preclinical

Authors

RDR.A.L. DampneyGeneral Cardiology MKMasanobu KumadaTokyo University of Agriculture DRD.J. ReisSecretaria Municipal de Cultura

Discussion

Member takes

Implication

Medullary nuclei mediate ischemic responses in rabbits; hypothesis-generating for human cerebral ischemia mechanisms.

Structured PICO

Population

Anesthetized rabbits

Intervention

Cerebral ischemia induced by clamping both common carotid arteries after occluding vertebral arteries; brainstem/cranial nerve transections; electrical stimulation of medulla oblongata

Comparator

Baseline or intact state

Outcome

Cardiovascular and respiratory responses (arterial hypertension, bradycardia, apnea, regional blood flow changes)surrogate

The cerebral ischemic response is driven by direct stimulation of medullary neurons, with specific nuclei mediating distinct vasomotor and cardiac components.

Cite This Study

Dampney et al. (1979) studied this question.

synapsesocial.com/papers/6a23e9c698edd3e1959eea33 https://doi.org/10.1161/01.res.45.1.48

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Central neural mechanisms of the cerebral ischemic response. Characterization, effect of brainstem and cranial nerve transections, and simulation by electrical stimulation of restricted regions of medulla oblongata in rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Central neural mechanisms of the cerebral ischemic response. Characterization, effect of brainstem and cranial nerve transections, and simulation by electrical stimulation of restricted regions of medulla oblongata in rabbit.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider