Key result
Caldesmon interacts with the Cys-190 region of tropomyosin, altering its position on actin and constraining myosin-induced movement, providing a molecular basis for its inhibitory function.
Authors
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No immediate clinical application; extends in vitro evidence for caldesmon-mediated thin-filament regulation.
Graceffa et al. (2004) studied this question. Caldesmon was evaluated on Position and myosin-induced movement of smooth muscle tropomyosin bound to actin. Caldesmon interacts with the Cys-190 region of tropomyosin, altering its position on actin and constraining myosin-induced movement, providing a molecular basis for its inhibitory function.
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