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)-H thiolation of γ-lactam-derived tetrasubstituted alkenyl chlorides with 2-hydroxythiophenol, affording β-thio-α,β-unsaturated γ-lactams with high efficiency. The pendant phenolic hydroxyl group acts as a versatile synthetic handle, enabling diverse downstream functionalizations and underscoring the synthetic utility of the products. Preliminary mechanistic studies reveal a sequential rearrangement cascade in the catalytic cycle.
Hu et al. (Fri,) studied this question.