Key result
Remodelling of atrial gap junctions and connexins plays an important role in the stability of atrial fibrillation and represents a potentially new therapeutic target for controlling its progression.
This review highlights the role of gap junction and connexin remodeling in atrial fibrillation and suggests targeting this process could be a novel therapeutic approach.
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Should not change AF management; leaves open connexin targeting as a hypothesis-generating strategy.
Henk van der Velden (2002) conducted a review in Atrial fibrillation. Gap junctions and connexins was evaluated. Remodelling of atrial gap junctions and connexins plays an important role in the stability of atrial fibrillation and represents a potentially new therapeutic target for controlling its progression.
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