Key result
Cytoskeletal tropomyosin isoforms are spatially segregated and regulate dynamic interactions between actin and its binding proteins, facilitating the functional diversity of the actin cytoskeleton.
This review integrates studies to provide a unifying view of tropomyosin-dependent regulation of the actin cytoskeleton.
Does not yet support isoform-specific interventions in cardiac disease; extends unifying models of actin filament diversity.
The actin cytoskeleton plays a central role in many essential cellular processes. Its involvement requires actin filaments to form multiple populations with different structural and therefore functional properties in specific subcellular locations. This diversity is facilitated through the interaction between actin and a number of actin binding proteins. One family of proteins, the tropomyosins, are absolutely essential in regulating actin's ability to form such diverse structures. In this review we integrate studies from different organisms and cell types in an attempt to provide a unifying view of tropomyosin dependent regulation of the actin cytoskeleton.
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Vindin et al. (2013) reported a review. Tropomyosin isoforms was evaluated. Cytoskeletal tropomyosin isoforms are spatially segregated and regulate dynamic interactions between actin and its binding proteins, facilitating the functional diversity of the actin cytoskeleton.
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