February 10, 2004The Journal of PhysiologyOpen Access

Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility

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Population

Transgenic double mutation mouse lines (α-TM DM)

Comparison

Expression of mutated α-tropomyosin replacing… vs Native α-tropomyosin (implied)

Design

Preclinical

Authors

RGRobert D. GaffinDiscovery Institute KGKuppan GokulanNational Center for Toxicological Research JSJames C. SacchettiniBoston University

Discussion

Member takes

Implication

Alters cardiac mechanics via myofilament charge effects in mice; leaves open translation to human sarcomeric cardiomyopathies.

Structured PICO

Population

Transgenic double mutation mouse lines (α-TM DM)

Intervention

Expression of mutated α-tropomyosin (Ser229Glu + His276Asn) replacing 60-88% of native TM

Comparator

Native α-tropomyosin (implied)

Outcome

Cardiac muscle performance (rates of pressure development and relaxation, +dP/dt and -dP/dt) and Ca(2+) sensitivity of myofilamentssurrogate

Charge changes at the carboxy-terminal of α-tropomyosin alter the functional characteristics of the heart at both the whole organ and myofilament levels.

Cite This Study

Gaffin et al. (2004) studied this question.

synapsesocial.com/papers/6a240be99e1c90a91c099b23 https://doi.org/10.1113/jphysiol.2003.058487

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Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Charged residue changes in the carboxy‐terminus of α‐tropomyosin alter mouse cardiac muscle contractility

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider