February 1, 1999Journal of Cardiovascular Electrophysiology
The Molecular and Ionic Specificity of Antiarrhythmic Drug Actions
Design
Review
Authors
Discussion
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Member takes
Implication
May favor dual IKr/IKs blockers like amiodarone to limit torsades risk; leaves open targeted development of selective agents.
Structured PICO
I
Intervention
Antiarrhythmic drugs (Na+, K+, and Ca++ channel blockers)
Understanding the molecular basis of cardiac ion channels allows for the development of targeted antiarrhythmic drugs with specific channel-blocking profiles to minimize proarrhythmia.
Cite This Study
Stanley Nattel (1999) studied this question.