Key result
Congenital coronary artery anomalies, such as high take-off and acute downward angulation, can lead to global myocardial ischemia and sudden death in otherwise healthy young adults.
Case Report (n=1)
Highlights that congenital coronary artery anomalies, though uncommon, can cause sudden death due to myocardial ischemia and terminal ventricular dysrhythmia in young, otherwise healthy individuals.
Consider congenital coronary anomalies in sudden death evaluation of young adults; single case leaves open prevalence and screening needs.
Congenital anomalies of the coronary arteries are relatively uncommon conditions with an incidence of approximately 2% in the adult population. Although less common than acquired coronary artery disease, these anomalies may be associated with myocardial ischemia and its consequences; angina, arrhythmia, infarction, and sudden death. A 21-year-old female patient with no significant prior medical history was found dead at home. Postmortem examination revealed high take-off of the right coronary artery with acute down-ward angulation of the proximal right coronary artery and acute downward angulation of the left main coronary artery. Microscopic examination revealed global myocardial ischemia consistent with a terminal ventricular dysrhythmia. There was no evidence of any other disease processes. Detailed toxicological investigation was negative. The Regional Forensic Pathology Unit experience with sudden death due to congenital coronary artery anomalies is presented along with a review of the current literature.
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Rao et al. (1994) conducted a case report in Sudden death due to congenital coronary artery anomalies (n=1). Congenital coronary artery anomalies was evaluated on Sudden death. Congenital coronary artery anomalies, such as high take-off and acute downward angulation, can lead to global myocardial ischemia and sudden death in otherwise healthy young adults.
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