Key result
A geriatric approach based on functional status, frailty, and autonomy assessment is necessary for decision-making regarding antihypertensive therapy in very elderly patients.
Why the study?
Very elderly patients have significant functional heterogeneity and those with frailty or loss of autonomy were excluded from major trials, making a universal BP-lowering strategy inapplicable.
Should a geriatric approach based on functional status and frailty be used to guide antihypertensive therapy in older adults?
Should a geriatric approach based on functional status and frailty be used to guide antihypertensive therapy in older adults?
Antihypertensive therapy in older adults should be individualized based on a geriatric assessment of frailty and functional status rather than applying a universal blood pressure target.
Supports geriatric assessment to guide antihypertensive therapy in very elderly patients; leaves open optimal targets pending RCTs in frail subgroups.
Elevated blood pressure (BP) is an important risk factor not only for cardiovascular morbidity and mortality, but also for cognitive decline and loss of autonomy in later life. Randomized clinical trials (RCTs) in populations of older patients living at home with low comorbidity and preserved autonomy showed benefits of decreasing the elevated BP in patients older than 80 years. Older patients with frailty, loss of autonomy and other geriatric problems were systematically excluded from the RCTs. Observational studies in these groups of patients showed an increase in morbidity and mortality at a lower level of BP during antihypertensive therapy. Obviously, in very elderly patients a universal strategy for the BP lowering cannot be applied due to the significant heterogeneity of their functional status. In this review geriatric approach based on assessment of the functional status of the elderly patient, the presence of frailty and degree of loss of autonomy as a basis for decision-making process regarding the antihypertensive therapy is discussed.
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Kotovskaya et al. (2019) conducted a review in Arterial hypertension. Geriatric approach to antihypertensive therapy was evaluated. A geriatric approach based on functional status, frailty, and autonomy assessment is necessary for decision-making regarding antihypertensive therapy in very elderly patients.
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