Key result
In a systematic review of 11 studies including 83,438 patients, antimicrobial use in patients on warfarin therapy was associated with an increased risk of bleeding events and higher INRs.
Why the study?
Warfarin use is confined by bleeding concerns, motivating an investigation of drug-drug interactions between warfarin therapy and antimicrobials.
Does the use of antimicrobials increase the risk of bleeding and elevated INR in patients on warfarin therapy?
Comparison
Antimicrobial use in patients on warfarin therapy
Design
Systematic review
Authors
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Heightened bleeding risk warrants close INR monitoring with antimicrobials in warfarin patients; confirms interactions via large-scale evidence synthesis.
Systematic Review (n=83,438)
Does the use of antimicrobials increase the risk of bleeding and elevated INR in patients on warfarin therapy?
The concurrent use of antimicrobials in patients on warfarin therapy is associated with an increased risk of bleeding events and elevated INR, necessitating careful monitoring.
Sulayi et al. (2022) conducted a systematic review in Patients on warfarin therapy (n=83,438). Antimicrobials was evaluated on Bleeding events and increased INR. In a systematic review of 11 studies including 83,438 patients, antimicrobial use in patients on warfarin therapy was associated with an increased risk of bleeding events and higher INRs.
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