Key result
High eGFR ratio linked to ~96% higher risk of post-ablation AF recurrence.
Why the study?
Although the difference between cystatin C- and creatinine-based eGFR is associated with the risk of developing AF, its impact on AF ablation outcomes was unknown.
Does the baseline eGFR ratio (eGFRcys/eGFRcr) predict post-ablation outcomes in patients with atrial fibrillation?
Population
989 patients with AF undergoing ablation
Comparison
Baseline eGFR ratio (eGFRcys/eGFRcr) evaluated continuously and by centile categories
Design
Cohort study
Follow-up
Median 28 months
Authors
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Baseline eGFR ratio may flag higher post-ablation AF recurrence risk; leaves open its utility for risk stratification or trial enrichment.
Cohort (n=989)
Does the baseline eGFR ratio (eGFRcys/eGFRcr) predict post-ablation outcomes in patients with atrial fibrillation?
Hazard Ratio: 1.96 (95% CI 1.37–2.8)
Both low and high baseline eGFR ratios (eGFRcys/eGFRcr) are associated with an increased risk of atrial fibrillation recurrence after ablation.
Huang et al. (2025) conducted a cohort in Atrial fibrillation (n=989). eGFR ratio (eGFRcys/eGFRcr) vs. Second quartile of eGFR ratio was evaluated on AF recurrence and adverse events (HR 1.96, 95% CI 1.37-2.80). A high eGFR ratio (fourth quartile) was associated with an increased risk of post-ablation AF recurrence compared to the second quartile (HR 1.96; 95% CI 1.37-2.80).
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