Prevalence and Significance of an Early Repolarization Electrocardiographic Pattern and its Mechanistic Insight Based on Cardiac Magnetic Resonance Imaging in Patients with Acute Myocarditis
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Key result
In patients with acute myocarditis, the early repolarization ECG pattern was not associated with lethal ventricular tachyarrhythmias (0% vs 42.9% in non-ER patients, p=0.029).
Why the study?
The association between an early repolarization ECG pattern and lethal arrhythmias in patients with acute myocarditis was unknown.
Does an early repolarization ECG pattern predict the occurrence of lethal ventricular tachyarrhythmias in patients with acute myocarditis?
Population
30 patients with acute myocarditis (mean age 39.2 years, 23 men)
Comparison
Transient ER-ECG pattern (n=9) vs non-ER-ECG pattern with ST elevation or abnormal Q waves (n=21)
Authors
Discussion
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Implication
ER pattern may mark lower arrhythmia risk in acute myocarditis; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Observational (n=30)
Multicenter
No
Structured PICO
Does an early repolarization ECG pattern predict the occurrence of lethal ventricular tachyarrhythmias in patients with acute myocarditis?
P
Population
30 patients (mean age 39.2 years, 23.3% female) with acute myocarditis were retrospectively evaluated to investigate the clinical significance of the early repolarization ECG pattern.
E
Exposure
Presence of an early repolarization electrocardiogram (ER-ECG) pattern (n=9)
C
Comparator
Absence of an ER-ECG pattern (non-ER group, presenting with broad ST elevation or pathologic Q waves) (n=21)
O
Outcome
Development of lethal ventricular tachyarrhythmias (ventricular fibrillation/ventricular tachycardia)hard clinical
Main Result
Absolute Event Rate: 0% vs 42.9%
p-value: p=0.029
In patients with acute myocarditis, an early repolarization ECG pattern indicates localized epicardial inflammation and is associated with a benign clinical course without lethal ventricular arrhythmias.
Limitations
- Retrospective design
- Small sample size
- Single-center study
Cite This Study
Oka et al. (2022) conducted an observational in Acute myocarditis (n=30). Early repolarization electrocardiogram (ER-ECG) pattern vs. Non-ER-ECG pattern was evaluated on Development of lethal ventricular tachyarrhythmias (p=0.029). In patients with acute myocarditis, the early repolarization ECG pattern was not associated with lethal ventricular tachyarrhythmias (0% vs 42.9% in non-ER patients, p=0.029).
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