Key result
Systemic arterial stiffness was not significantly associated with the presence or severity of primary open angle glaucoma in Malay patients, although higher pulse wave velocity was found in those with disease progression.
Why the study?
Vascular dysregulation is postulated to be involved in the pathogenesis of primary open angle glaucoma (POAG), and systemic arterial stiffness may accelerate pre-existing damage.
Is systemic arterial stiffness associated with the severity and progression of visual field defects in Malay patients with primary open angle glaucoma?
Cross-Sectional (n=110)
Blinded investigators
No
Is systemic arterial stiffness associated with the severity and progression of visual field defects in Malay patients with primary open angle glaucoma?
p-value: p=0.333
Systemic arterial stiffness was not associated with POAG severity, but higher pulse wave velocity was observed in patients with visual field progression.
Arterial stiffness assessment should not inform POAG care in Malay patients; leaves open PWV's link to progression for prospective study.
Introduction: Vascular dysregulation is postulated to be involved in the pathogenesis of primary open angle glaucoma (POAG). Systemic arterial stiffness may accelerate the pre-existing damage. The purpose of this study was to determine the association of arterial stiffness with severity and progression of visual field in Malay patients with POAG. Methods: A cross-sectional study was conducted with 55 patients with POAG and 55 age- and sex-matched control subjects. The patients with POAG were further divided in accordance with their Advanced Glaucoma Intervention Study (AGIS) scores on their visual fields (VFs) (mild in 23 patients, moderate in 18, and severe in 14). Progression was defined as the worsening of the VF defect quantified as an increase in AGIS score of 4 points from the baseline. Arterial stiffness was measured using SphygmoCor and quantified as pulse wave analysis (PWA) and pulse wave velocity (PWV). Results: No significant differences in PWA and PWV were found between the patients with POAG and the control subjects (p=0.333 and p=0.443, respectively). The mean follow-up duration for the patients with POAG was 4.7±3.1 years. PWA and PWV showed no significant association with POAG severity after the confounding factors were controlled for. Ten patients with progression of VF were identified. In the analysis of covariance, a significantly higher PWV was found in the patients with disease progression (p=0.036). Conclusion: VF severity and progression were not associated with systemic arterial stiffness. The probable reason is that other factors affecting retinal microcirculation may play a larger role in the severity and progression of POAG.
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Kiu et al. (2022) conducted a cross-sectional in Primary Open Angle Glaucoma (n=110). Systemic arterial stiffness vs. Control subjects without glaucoma was evaluated on Difference in Pulse Wave Analysis (PWA) between POAG patients and controls (p=0.333). Systemic arterial stiffness was not significantly associated with the presence or severity of primary open angle glaucoma in Malay patients, although higher pulse wave velocity was found in those with disease progression.
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