Key result
Diabetes mellitus was associated with time-dependent coronary microvascular impairment, showing increased baseline flow velocity early (P=0.008) and reduced hyperemic flow late (P<0.001).
Why the study?
Does diabetes mellitus duration affect coronary microvascular function and autoregulation in patients with normal epicardial coronary arteries?
Population
102 patients (55 diabetic and 47 nondiabetic) with normal epicardial coronary arteries on angiography
Comparison
Diabetes mellitus vs Nondiabetic patients
Design
Cross-sectional
Authors
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Cross-sectional data warrant no practice change; leaves open prospective studies on diabetes duration and microvascular outcomes.
Observational (n=102)
Does diabetes mellitus duration affect coronary microvascular function and autoregulation in patients with normal epicardial coronary arteries?
p-value: p=<0.001
Diabetes mellitus causes a time-dependent bimodal impairment of coronary microcirculation, starting with functional autoregulatory impairment (overperfusion) and evolving into structural microvascular impairment.
Sezer et al. (2016) conducted an observational in Diabetes Mellitus (n=102). Diabetes Mellitus vs. Nondiabetic patients was evaluated on Coronary flow velocity reserve and microvascular resistance (p=<0.001). Diabetes mellitus was associated with time-dependent coronary microvascular impairment, showing increased baseline flow velocity early (P=0.008) and reduced hyperemic flow late (P<0.001).
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